Article
The Protein Acyl Transferase ZDHHC21 Modulates α1 Adrenergic Receptor Function and Regulates Hemodynamics.
Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2016
Marin Ethan P, Jozsef Levente, Di Lorenzo Annarita, Held Kara F, Luciano Amelia K, Melendez Jonathan, Milstone Leonard M, Velazquez Heino, Sessa William C
Abstract excerpt
OBJECTIVE: Palmitoylation, the reversible addition of the lipid palmitate to a cysteine, can alter protein localization, stability, and function. The ZDHHC family of protein acyl transferases catalyzes palmitoylation of numerous proteins. The role of ZDHHC enzymes in intact tissue and in vivo is largely unknown. Herein, we characterize vascular functions in a mouse that expresses a nonfunctional ZDHHC21 (F233Δ)....
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