DHHC7-mediated palmitoylation of the accessory protein barttin critically regulates the functions of ClC-K chloride channels.

doi:10.1074/jbc.RA119.011049

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Article

DHHC7-mediated palmitoylation of the accessory protein barttin critically regulates the functions of ClC-K chloride channels.

The Journal of biological chemistry - 1 May 2020

Gorinski Nataliya, Wojciechowski Daniel, Guseva Daria, Abdel Galil Dalia, Mueller Franziska E, Wirth Alexander, Thiemann Stefan, Zeug Andre, Schmidt Silke, Zareba-Kozioł Monika, Wlodarczyk Jakub, Skryabin Boris V, Glage Silke, Fischer Martin, Al-Samir Samer, Kerkenberg Nicole, Hohoff Christa, Zhang Weiqi, Endeward Volker, Ponimaskin Evgeni

Abstract excerpt

Barttin is the accessory subunit of the human ClC-K chloride channels, which are expressed in both the kidney and inner ear. Barttin promotes trafficking of the complex it forms with ClC-K to the plasma membrane and is involved in activating this channel. Barttin undergoes post-translational palmitoylation that is essential for its functions, but the enzyme(s) catalyzing this post-translational modification is...

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PMID: 32184353
DOI: 10.1074/jbc.RA119.011049
PMCID: PMC7196637

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