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Article

Palmitoyl Acyltransferase Activity of ZDHHC13 Regulates Skin Barrier Development Partly by Controlling PADi3 and TGM1 Protein Stability.

The Journal of investigative dermatology - 1 May 2020

Chen Li-Ying, Lin Kuo-Ray, Chen Yi-Ju, Chiang Yun-Jung, Ho Kun-Chin, Shen Li-Fen, Song I-Wen, Liu Kai-Ming, Yang-Yen Hsin-Fang, Chen Yu-Ju, Chen Yuan-Tsong, Liu Fu-Tong, Yen Jeffrey J Y

Abstract excerpt

Deficiency of the palmitoyl-acyl transferase ZDHHC13 compromises skin barrier permeability and renders mice susceptible to environmental bacterial infection and inflammatory dermatitis. It had been unclear how the lack of ZDHHC13 proteins resulted in cutaneous abnormalities. In this study, we first demonstrate that enzymatic palmitoylation activity, rather than protein scaffolding, by ZDHHC13 is essential for...

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PMID: 31669413
DOI: 10.1016/j.jid.2019.09.017

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