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Article

Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension.

Circulation - 4 Jan 2005

Gainer James V, Bellamine Aouatef, Dawson Elliott P, Womble Kristie E, Grant Sarah W, Wang Yarong, Cupples L Adrienne, Guo Chao-Yu, Demissie Serkalem, O'Donnell Christopher J, Brown Nancy J, Waterman Michael R, Capdevila Jorge H

Abstract excerpt

BACKGROUND: The CYP4A11 arachidonic acid monooxygenase oxidizes endogenous arachidonic acid (AA) to 20-hydroxyeicosatetraenoic acid (20-HETE), a metabolite with renovascular and tubular functions. Mice with targeted disruption of Cyp4a14, a murine homologue of CYP4A11, have severe hypertension. We combined molecular and biochemical approaches to identify a functional variant of the CYP4A11 20-HETE synthase and...

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PMID: 15611369
DOI: 10.1161/01.CIR.0000151309.82473.59

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension.PMID 15611369Read ↗

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