Article

S-Palmitoylation-Dependent Regulation of Cardiomyocyte Rac1 Signaling Activity and Cardiac Hypertrophy

2021-05-15

Abstract excerpt

<h4>ABSTRACT</h4> S-palmitoylation is a reversible lipid modification that regulates trafficking, localization, activity, and/or stability of protein substrates by serving as a fatty acid anchor to cell membranes. However, S-palmitoylation-dependent control of signal transduction in cardiomyocytes and its effects on cardiac physiology are not well understood. We performed an in vivo gain-of-function screen of zin...

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Literature Corpus work: ad962fbe-5929-5d81-8165-d9a7fabbecf7
DOI: 10.1101/2021.05.14.444015

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