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Article

Editing of the myosin phosphatase regulatory subunit suppresses angiotensin II induced hypertension via sensitization to nitric oxide mediated vasodilation.

Pflugers Archiv : European journal of physiology - 1 Apr 2021

Htet Myo, Ursitti Jeanine A, Chen Ling, Fisher Steven A

Abstract excerpt

Alternative splicing of exon 24 (E24) of the myosin phosphatase regulatory subunit (Mypt1) tunes smooth muscle sensitivity to NO/cGMP-mediated vasorelaxation and thereby controls blood pressure (BP) in otherwise normal mice. This occurs via the toggling in or out of a C-terminal leucine zipper (LZ) motif required for hetero-dimerization with and activation by cGMP-dependent protein kinase cGK1α. Here we tested...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33145641
DOI: 10.1007/s00424-020-02488-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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