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Article

A splice variant of the myosin phosphatase regulatory subunit tunes arterial reactivity and suppresses response to salt loading.

American journal of physiology. Heart and circulatory physiology - 1 Jun 2016

Reho John J, Kenchegowda Doreswamy, Asico Laureano D, Fisher Steven A

Abstract excerpt

The cGMP activated kinase cGK1α is targeted to its substrates via leucine zipper (LZ)-mediated heterodimerization and thereby mediates vascular smooth muscle (VSM) relaxation. One target is myosin phosphatase (MP), which when activated by cGK1α results in VSM relaxation even in the presence of activating calcium. Variants of MP regulatory subunit Mypt1 are generated by alternative splicing of the 31 nt exon 24...

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Identifiers

PMID: 27084390
DOI: 10.1152/ajpheart.00869.2015
PMCID: PMC4935519

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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