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Article

Structure and function of DHHC protein S-acyltransferases.

Biochemical Society transactions - 15 Aug 2017

Gottlieb Colin D, Linder Maurine E

Abstract excerpt

It has been estimated that 10% of the human genome encodes proteins that are fatty acylated at cysteine residues. The vast majority of these proteins are modified by members of the DHHC protein family, which carry out their enzymatic function on the cytoplasmic face of cell membranes. The biomedical importance of DHHC proteins is underscored by their association with human disease; unique and essential roles for...

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Identifiers

PMID: 28630137
DOI: 10.1042/BST20160304

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