Article
Mice with alopecia, osteoporosis, and systemic amyloidosis due to mutation in Zdhhc13, a gene coding for palmitoyl acyltransferase.
PLoS genetics - 10 Jun 2010
Saleem Amir N, Chen Yen-Hui, Baek Hwa Jin, Hsiao Ya-Wen, Huang Hong-Wen, Kao Hsiao-Jung, Liu Kai-Ming, Shen Li-Fen, Song I-Wen, Tu Chen-Pei D, Wu Jer-Yuarn, Kikuchi Tateki, Justice Monica J, Yen Jeffrey J Y, Chen Yuan-Tsong
Abstract excerpt
Protein palmitoylation has emerged as an important mechanism for regulating protein trafficking, stability, and protein-protein interactions; however, its relevance to disease processes is not clear. Using a genome-wide, phenotype driven N-ethyl-N-nitrosourea-mediated mutagenesis screen, we identified mice with failure to thrive, shortened life span, skin and hair abnormalities including alopecia, severe...
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