Article
DHHC protein-dependent palmitoylation protects regulator of G-protein signaling 4 from proteasome degradation.
FEBS letters - 19 Nov 2010
Wang Jincheng, Xie Yan, Wolff Dennis W, Abel Peter W, Tu Yaping
Abstract excerpt
Regulator of G-protein signaling 4 (RGS4), an intracellular modulator of G-protein coupled receptor (GPCR)-mediated signaling, is regulated by multiple processes including palmitoylation and proteasome degradation. We found that co-expression of DHHC acyltransferases (DHHC3 or DHHC7), but not their acyltransferase-inactive mutants, increased expression levels of RGS4 but not its Cys2 to Ser mutant (RGS4C2S)....
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