Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IL35-Producing B Cells Promote the Development of Pancreatic Neoplasia.

Cancer discovery - 1 Mar 2016

Pylayeva-Gupta Yuliya, Das Shipra, Handler Jesse S, Hajdu Cristina H, Coffre Maryaline, Koralov Sergei B, Bar-Sagi Dafna

Abstract excerpt

UNLABELLED: A salient feature of pancreatic ductal adenocarcinoma (PDAC) is an abundant fibroinflammatory response characterized by the recruitment of immune and mesenchymal cells and the consequent establishment of a protumorigenic microenvironment. Here, we report the prominent presence of B cells in human pancreatic intraepithelial neoplasia and PDAC lesions as well as in oncogenic Kras-driven pancreatic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes
Share to Biomarkers
Share to Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

Share to Immunohistochemistry

Share to Interleukins

Share to Lymphocytes, Tumor-Infiltrating

Share to Pancreatic Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 26715643
DOI: 10.1158/2159-8290.CD-15-0843
PMCID: PMC5709038

Genes

CD5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IL35-Producing B Cells Promote the Development of Pancreatic Neoplasia.PMID 26715643Read ↗

B cell c-Maf signaling promotes tumor progression in animal models of pancreatic cancer and melanomaSemantic proximity Read ↗

3D histology reveals that immune response to pancreatic precancers is heterogeneous and depends on global pancreas structureSemantic proximity Read ↗

CD4+ T Lymphocyte Ablation Prevents Pancreatic Carcinogenesis in MiceSemantic proximity Read ↗

IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8+ T cells Infiltrating Pancreatic Ductal AdenocarcinomaSemantic proximity Read ↗

Pancreatic cancer triggers diabetes through TGF-β–mediated selective depletion of islet β-cellsSemantic proximity Read ↗

Spatial and phenotypic plasticity of B cells in remodeling the tumor microenvironment.Semantic proximity Read ↗

Mir34a constrains pancreatic carcinogenesis.Semantic proximity Read ↗

Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancerSemantic proximity Read ↗

STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis.Semantic proximity Read ↗

Preventive Treatment with a CD73 Small Molecule Inhibitor Enhances Immune Surveillance in K-Ras Mutant Pancreatic Intraepithelial Neoplasia.Semantic proximity Read ↗

Mucin (Muc) expression during pancreatic cancer progression in spontaneous mouse model: potential implications for diagnosis and therapy.Semantic proximity Read ↗

Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.