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Article

Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer

4 Apr 2017

Abstract excerpt

Abstract Pancreatic ductal adenocarcinoma (PDAC) driven by oncogenic K-Ras remains among the most lethal human cancers despite recent advances in modern medicine. The pathogenesis of PDAC is partly attributable to intrinsic chromosome instability and extrinsic inflammation activation. However, the molecular link between these two events in pancreatic tumorigenesis has not yet been fully established. Here, we show...

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PMID: 28374746
DOI: 10.1038/cr.2017.51

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