Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic association of long-chain acyl-CoA synthetase 1 variants with fasting glucose, diabetes, and subclinical atherosclerosis.

Journal of lipid research - 1 Mar 2016

Manichaikul Ani, Wang Xin-Qun, Zhao Wei, Wojczynski Mary K, Siebenthall Kyle, Stamatoyannopoulos John A, Saleheen Danish, Borecki Ingrid B, Reilly Muredach P, Rich Stephen S, Bornfeldt Karin E

Abstract excerpt

Long-chain acyl-CoA synthetase 1 (ACSL1) converts free fatty acids into acyl-CoAs. Mouse studies have revealed that ACSL1 channels acyl-CoAs to β-oxidation, thereby reducing glucose utilization, and is required for diabetes-accelerated atherosclerosis. The role of ACSL1 in humans is unknown. We therefore examined common variants in the human ACSL1 locus by genetic association studies for fasting glucose, diabetes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atherosclerosis
Share to Black or African American

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Blood Glucose

Share to Calcinosis

Share to Chromatin

Share to Coenzyme A Ligases

Share to Coronary Artery Disease

Share to Fasting

Source

Open in PubMed Open full text

Identifiers

PMID: 26711138
DOI: 10.1194/jlr.M064592
PMCID: PMC4766992

Genes

ACSL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic association of long-chain acyl-CoA synthetase 1 variants with fasting glucose, diabetes, and subclinical atherosclerosis.PMID 26711138Read ↗

Genome-wide association study reveals shared and distinct genetic architecture underlying fatty acid and bioactive oxylipin metabolites in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)Semantic proximity Read ↗

Genome-wide association study reveals shared and distinct genetic architecture of fatty acids and oxylipins in the Hispanic Community Health Study/Study of Latinos.Semantic proximity Read ↗

Genetic Variation of Human Long-Chain Fatty Acyl-CoA Synthetase and Nutritional Implication.Semantic proximity Read ↗

LIPA, a risk locus for coronary artery disease: decoding the variant-to-function relationship.Semantic proximity Read ↗

Multiethnic Genome-Wide Association Study of Subclinical Atherosclerosis in Individuals With Type 2 Diabetes.Semantic proximity Read ↗

Decoding the variant-to-function relationship for <i>LIPA</i> , a risk locus for coronary artery diseaseSemantic proximity Read ↗

The influence of rare variants in circulating metabolic biomarkersSemantic proximity Read ↗

Gene-nutrient interactions with dietary fat modulate the association between genetic variation of the ACSL1 gene and metabolic syndrome.Semantic proximity Read ↗

Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1.Semantic proximity Read ↗

Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study.Semantic proximity Read ↗

Variants in ACAD10 are associated with type 2 diabetes, insulin resistance and lipid oxidation in Pima Indians.Semantic proximity Read ↗

Acyl-Coenzyme A: Cholesterol Acyltransferase (ACAT) in Cholesterol Metabolism: From Its Discovery to Clinical Trials and the Genomics EraSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.