Article

The influence of rare variants in circulating metabolic biomarkers

2018-11-29

Abstract excerpt

Circulating metabolite levels are biomarkers for cardiovascular disease (CVD). We tested association between rare sequence variants and 226 serum lipoproteins, lipids and amino acids in 7,142 healthy participants. Gene-based association analyses identified novel gene-trait associations with ACSL1 , MYCN , FBXO36 and B4GALNT3 ( p <2.5 × 10 −6 ), and confirmed established associations. Regulation of the pyruva...

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Literature Corpus work: 2a055f6d-f7c8-50bb-82f2-a8a583bfb310
DOI: 10.1101/480699

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