Article
Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1.
Proceedings of the National Academy of Sciences of the United States of America - 20 Mar 2012
Kanter Jenny E, Kramer Farah, Barnhart Shelley, Averill Michelle M, Vivekanandan-Giri Anuradha, Vickery Thad, Li Lei O, Becker Lev, Yuan Wei, Chait Alan, Braun Kathleen R, Potter-Perigo Susan, Sanda Srinath, Wight Thomas N, Pennathur Subramaniam, Serhan Charles N, Heinecke Jay W, Coleman Rosalind A, Bornfeldt Karin E
Abstract excerpt
The mechanisms that promote an inflammatory environment and accelerated atherosclerosis in diabetes are poorly understood. We show that macrophages isolated from two different mouse models of type 1 diabetes exhibit an inflammatory phenotype. This inflammatory phenotype associates with increased expression of long-chain acyl-CoA synthetase 1 (ACSL1), an enzyme that catalyzes the thioesterification of fatty acids....
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