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Article

Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study.

Mediators of inflammation - 1 Jan 2010

Burdon Kathryn P, Rudock Megan E, Lehtinen Allison B, Langefeld Carl D, Bowden Donald W, Register Thomas C, Liu Yongmei, Freedman Barry I, Carr J Jeffrey, Hedrick Catherine C, Rich Stephen S

Abstract excerpt

AIMS: Genes of the 5-lipoxygenase pathway are compelling candidates for atherosclerosis. We hypothesize that polymorphisms in ALOX12, ALOX15, ALOX5, and ALOX5AP genes are associated with subclinical atherosclerosis in multiple vascular beds. METHODS: Families with two or more siblings with type 2 diabetes and their nondiabetic siblings were studied as part of the Diabetes Heart Study (DHS). European American...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20592751
DOI: 10.1155/2010/170153
PMCID: PMC2878676

Genes

ALOX12
ALOX5
ALOX15
CRP
MGP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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