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Article

X region mutations of hepatitis B virus related to clinical severity.

World journal of gastroenterology - 28 Jun 2016

Kim Hong, Lee Seoung-Ae, Kim Bum-Joon

Abstract excerpt

Chronic hepatitis B virus (HBV) infection remains a major health problem, with more than 240 million people chronically infected worldwide and potentially 650000 deaths per year due to advanced liver diseases including liver cirrhosis and hepatocellular carcinoma (HCC). HBV-X protein (HBx) contributes to the biology and pathogenesis of HBV via stimulating virus replication or altering host gene expression related...

Topics

Carcinoma, Hepatocellular
Hepatitis B virus
Hepatitis B, Chronic
Humans
Liver Neoplasms
Mutation
Promoter Regions, Genetic
Severity of Illness Index
Trans-Activators
Viral Regulatory and Accessory Proteins
Virus Replication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27350725
DOI: 10.3748/wjg.v22.i24.5467
PMCID: PMC4917607

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-27350725-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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