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Article

ABCB1 Genetic Effects on Antidepressant Outcomes: A Report From the iSPOT-D Trial.

The American journal of psychiatry - 1 Aug 2015

Schatzberg Alan F, DeBattista Charles, Lazzeroni Laura C, Etkin Amit, Murphy Greer M, Williams Leanne M

Abstract excerpt

OBJECTIVE: The ABCB1 gene encodes P-glycoprotein, which limits brain concentrations of certain antidepressants. ABCB1 variation has been associated with antidepressant efficacy and side effects in small-sample studies. Cognitive impairment in major depressive disorder predicts poor treatment outcome, but ABCB1 genetic effects in patients with cognitive impairment are untested. The authors examined ABCB1 genetic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25815420
DOI: 10.1176/appi.ajp.2015.14050680

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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