Article
Integrative genomic analysis reveals widespread enhancer regulation by p53 in response to DNA damage
16 Apr 2015
Abstract excerpt
The tumor suppressor p53 has been studied extensively as a direct transcriptional activator of protein-coding genes. Recent studies, however, have shed light on novel regulatory functions of p53 within noncoding regions of the genome. Here, we use a systematic approach that integrates transcriptome-wide expression analysis, genome-wide p53 binding profiles and chromatin state maps to characterize the global...
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