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Article

Charting the regulatory landscape of TP53 on transposable elements in cancer.

Genome research - 2 Jun 2025

Qu Xuan, Liang Yonghao, McCornack Colin, Xing Xiaoyun, Schmidt Heather, Tomlinson Chad, Fronick Catrina, Belter Edward A, Macias-Velasco Juan F, Wang Ting

Abstract excerpt

The relationship between TP53 and transposable elements (TEs) has been obscure. Given the important role of TEs in oncogenesis, a comprehensive profiling of TE expression dynamics under the regulation of TP53 provides valuable resources for more clarity in TP53's roles in cancer. In this study, we characterized the TE transcriptomic landscape using long-read RNA-seq and short-read RNA-seq in three cancer cell...

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Share to Cell Line, Tumor
Share to DNA Transposable Elements

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

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Share to Neoplasms

Share to Promoter Regions, Genetic

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Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 40360186
DOI: 10.1101/gr.279398.124
PMCID: PMC12129084

Genes

TP53

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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