Article
Rapid sensitive analysis of IDH1 mutation in lower-grade gliomas by automated genetic typing involving a quenching probe.
Cancer investigation - 1 Jan 2016
Kurimoto Michihiro, Suzuki Hiromichi, Aoki Kosuke, Ohka Fumiharu, Kondo Goro, Motomura Kazuya, Iijima Kentaro, Yamamichi Akane, Ranjit Melissa, Wakabayashi Toshihiko, Kimura Shinya, Natsume Atsushi
Abstract excerpt
The authors recently found that 80% of lower-grade gliomas (LGGs) harbored a mutation in IDH1. Intraoperative detection of the mutated IDH1 helps not only differentiate LGGs from other type of brain tumors, but determine the resection border. In the current study, the authors have applied an automated genetic typing involving a quenching probe to detect the mutated IDH1. If tumor cells with the mutated IDH1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.