Rapid intraoperative genetic analysis of adult-type diffuse gliomas using a microfluidic real-time polymerase chain reaction device.

doi:10.1093/neuonc/noaf188

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Article

Rapid intraoperative genetic analysis of adult-type diffuse gliomas using a microfluidic real-time polymerase chain reaction device.

Neuro-oncology - 1 Dec 2025

Maeda Sachi, Kitano Yotaro, Ohka Fumiharu, Motomura Kazuya, Aoki Kosuke, Deguchi Shoichi, Shiba Yoshiki, Seki Masafumi, Ikeda Yuma, Shimizu Hiroki, Iwami Kenichiro, Takeuchi Kazuhito, Nagata Yuichi, Yamaguchi Junya, Kimura Keisuke, Takido Yuhei, Yamamoto Ryo, Nakamura Akihiro, Ito Shohei, Shinjo Keiko, Kondo Yutaka, Miyagi Shohei, Karube Kennosuke, Saito Ryuta

Abstract excerpt

BACKGROUND: The 5th edition of the World Health Organization Classification of Tumors of the CNS introduced a subclassification of tumors based on key molecular markers. In adult-type diffuse gliomas, isocitrate dehydrogenase (IDH) and telomerase reverse transcriptase (TERT) promoter mutations play pivotal roles in the molecular classification. This study developed a rapid genotyping system using GeneSoC, a...

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Identifiers

PMID: 40851364
DOI: 10.1093/neuonc/noaf188
PMCID: PMC12965051

Genes

IDH1
TERT

Variants

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