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Article

Microfluidics for rapid detection of isocitrate dehydrogenase 1 mutation for intraoperative application.

Journal of neurosurgery - 1 Jun 2016

Aibaidula Abudumijiti, Zhao Wang, Wu Jin-Song, Chen Hong, Shi Zhi-Feng, Zheng Lu-Lu, Mao Ying, Zhou Liang-Fu, Sui Guo-Dong

Abstract excerpt

OBJECT Conventional methods for isocitrate dehydrogenase 1 (IDH1) detection, such as DNA sequencing and immunohistochemistry, are time- and labor-consuming and cannot be applied for intraoperative analysis. To develop a new approach for rapid analysis of IDH1 mutation from tiny tumor samples, this study used microfluidics as a method for IDH1 mutation detection. METHODS Forty-seven glioma tumor samples were used;...

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Identifiers

PMID: 26544771
DOI: 10.3171/2015.4.JNS141833

Genes

IDH1

Variants

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