Article
IDH1 mutation analysis in low cellularity specimen: a limitation of diagnostic accuracy and a proposal for the diagnostic procedure.
Pathology, research and practice - 1 May 2013
Choi Junjeong, Lee Eun Young, Shin Kyung-Jin, Minn Yang-Ki, Kim Jieun, Kim Se Hoon
Abstract excerpt
Recently, new techniques for detecting IDH1 mutations have been developed. Most studies assessed the mutation status in glioma tissue without consideration of the size of the samples. We assessed the mutation status of IDH1 in simulated small biopsied tissue from 5 low grade gliomas, prepared by grid cutting procedure with direct sequencing, IDH1 immunohistochemistry (IHC), multiplex PCR with single base...
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