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Article

Cytotoxic human CD4(+) T cells.

Current opinion in immunology - 1 Jun 2008

van de Berg Pablo J, van Leeuwen Ester M, ten Berge Ineke J, van Lier Rene

Abstract excerpt

The induction of adaptive immune responses critically depends on helper signals provided by CD4(+) T cells. These signals not only license antigen presenting cells (APC) to activate naïve CD8(+) T cells leading to the formation of vast numbers of cytotoxic T lymphocytes but also support the differentiation of B cells into immunoglobulin-secreting plasma cells. Next to these helper functions, a subpopulation of...

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Identifiers

PMID: 18440213
DOI: 10.1016/j.coi.2008.03.007

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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