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Article

Behavioral phenotyping of minipigs transgenic for the Huntington gene.

Journal of neuroscience methods - 30 May 2016

Schramke Sarah, Schuldenzucker Verena, Schubert Robin, Frank Frauke, Wirsig Maike, Ott Stefanie, Motlik Jan, Fels Michaela, Kemper Nicole, Hölzner Eva, Reilmann Ralf

Abstract excerpt

BACKGROUND: While several novel therapeutic approaches for HD are in development, resources to conduct clinical trials are limited. Large animal models have been proposed to improve assessment of safety, tolerability and especially to increase translational reliability of efficacy signals obtained in preclinical studies. They may thus help to select candidates for translation to human studies. We here introduce a...

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PMID: 26688470
DOI: 10.1016/j.jneumeth.2015.11.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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