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Article

A Transgenic Minipig Model of Huntington's Disease

1 Jan 2013

Abstract excerpt

BACKGROUND: Some promising treatments for Huntington's disease (HD) may require pre-clinical testing in large animals. Minipig is a suitable species because of its large gyrencephalic brain and long lifespan. OBJECTIVE: To generate HD transgenic (TgHD) minipigs encoding huntingtin (HTT)1-548 under the control of human HTT promoter. METHODS: Transgenesis was achieved by lentiviral infection of porcine embryos. PCR...

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PMID: 25063429
DOI: 10.3233/jhd-130001

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