Article
Transgenic minipig model of Huntington's disease exhibiting gradually progressing neurodegeneration.
Disease models & mechanisms - 12 Dec 2019
Ardan Taras, Baxa Monika, Levinská Božena, Sedláčková Miroslava, Nguyen The Duong, Klíma Jiří, Juhás Štefan, Juhásová Jana, Šmatlíková Petra, Vochozková Petra, Motlík Jan, Ellederová Zdenka
Abstract excerpt
Recently developed therapeutic approaches for the treatment of Huntington's disease (HD) require preclinical testing in large animal models. The minipig is a suitable experimental animal because of its large gyrencephalic brain, body weight of 70-100 kg, long lifespan, and anatomical, physiological and metabolic resemblance to humans. The Libechov transgenic minipig model for HD (TgHD) has proven useful for proof...
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