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Article

Early behavioral deficits in R6/2 mice suitable for use in preclinical drug testing.

Neurobiology of disease - 1 Oct 2005

Hickey M A, Gallant K, Gross G G, Levine M S, Chesselet Marie-Françoise

Abstract excerpt

Huntington's disease (HD) is a neurodegenerative disorder caused by an elongated glutamine repeat in huntingtin. Improved understanding of the molecular effects of the mutation opens new avenues for treatment. High-throughput automated behavioral tests that produce well-defined markers of disease progression are necessary for in vivo drug screening. We have identified early behavioral deficits in tests of motor...

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Source

Identifiers

PMID: 16137562
DOI: 10.1016/j.nbd.2005.01.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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