Article
NeuroScale, the battery of behavioral tests with novel scoring system for phenotyping of transgenic rat model of tauopathy.
Journal of neuroscience methods - 15 Feb 2009
Korenova Miroslava, Zilka Norbert, Stozicka Zuzana, Bugos Ondrej, Vanicky Ivo, Novak Michal
Abstract excerpt
We have previously shown that transgenic rats expressing misfolded tau protein developed neurofibrillary tangles and axonal degeneration in the brain and spinal cord, which led to impairment of sensorimotor and neuromuscular functions. To quantify neurobehavioral phenotype of the transgenic rats we have designed a testing protocol and a novel scoring system - NeuroScale - that reliably reflects progression of...
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