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Article

Tolerogenic Dendritic Cells Generated by In Vitro Treatment With SAHA Are Not Stable In Vivo.

Cell transplantation - 1 Jan 2016

Thewissen Kristof, Broux Bieke, Hendriks Jerome J A, Vanhees Mandy, Stinissen Piet, Slaets Helena, Hellings Niels

Abstract excerpt

The aim of this study is to examine whether the histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), can generate dendritic cells (DCs) with a stable tolerogenic phenotype to counteract autoimmune responses in an animal model of multiple sclerosis. We investigated if the tolerogenic potency of DCs could be increased by continuous treatment during in vitro differentiation toward DCs compared to...

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Source

Identifiers

PMID: 26688298
DOI: 10.3727/096368915X690305

Genes

STAT1
STAT6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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