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Article

Therapeutical doses of temozolomide do not impair the function of dendritic cells and CD8+ T cells.

International journal of oncology - 1 Mar 2012

Xu Xun, Stockhammer Florian, Schmitt Anita, Casalegno-Garduno Rosaely, Enders Anne, Mani Jiju, Classen Carl Friedrich, Linnebacher Michael, Freund Mathias, Schmitt Michael

Abstract excerpt

The median survival of patients with glioblastoma multiforme (GBM) remains poor. Innovative immunotherapies with dendritic cell (DC) vaccination might be combined with standard temozolomide (TMZ) treatment. Here, we evaluated the influence of TMZ on the phenotype and function of DCs and CD8+ T cells. DCs were generated from the peripheral blood of healthy volunteers (HVs) and GBM patients. DCs were analyzed by...

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Identifiers

PMID: 22134728
DOI: 10.3892/ijo.2011.1269

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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