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Suberoylanilide hydroxamic acid induces limited changes in the transcriptome of primary CD4+ T cells

6 Dec 2012

Abstract excerpt

OBJECTIVE: To assess the off-target effects of the histone deacetylase inhibitor (HDACi) suberoylanilide hydroxamic acid (SAHA) in human primary CD4 T cells. DESIGN: A pharmacologically relevant concentration (340 nmol/l) of SAHA was shown to significantly increase histone hyperacetylation by 24 h and this length of treatment was selected to determine its impact on gene expression in primary CD4 T cells. METHODS:...

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PMID: 23221426
DOI: 10.1097/qad.0b013e32835b3e26

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