Article
Maturation of human dendritic cells as sulfasalazine target.
Croatian medical journal - 1 Aug 2001
Matasić R, Dietz A B, Vuk-Pavlović S
Abstract excerpt
AIM: Sulfasalazine, a nonsteroidal anti-inflammatory drug, is effective in treating some autoimmune diseases, but its mechanism of action is unclear. To determine whether dendritic cells could be a possible target of the drug, we studied the effects of sulfasalazine and its metabolites, aminosalicylate and sulfapyridine, on in vitro maturation (terminal differentiation) of human myeloid dendritic cells. METHODS:...
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