Article
The histone demethylase inhibitor GSK-J4 limits inflammation through the induction of a tolerogenic phenotype on DCs.
Journal of autoimmunity - 1 Dec 2016
Doñas Cristian, Carrasco Macarena, Fritz Macarena, Prado Carolina, Tejón Gabriela, Osorio-Barrios Francisco, Manríquez Valeria, Reyes Paz, Pacheco Rodrigo, Bono María Rosa, Loyola Alejandra, Rosemblatt Mario
Abstract excerpt
As it has been established that demethylation of lysine 27 of histone H3 by the lysine-specific demethylase JMJD3 increases immune responses and thus elicits inflammation, we hypothesize that inhibition of JMJD3 may attenuate autoimmune disorders. We found that in vivo administration of GSK-J4, a selective inhibitor of JMJD3 and UTX, ameliorates the severity of experimental autoimmune encephalomyelitis (EAE)....
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