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Article

Oncodevelopmental plasticity of the skeleton in myeloid neoplasms

2026-03-21

Abstract excerpt

Myelofibrosis in patients with myeloproliferative neoplasms (MPNs) is traditionally characterized by bone marrow fibrosis and osteosclerosis, with de novo bone formation commonly attributed to impaired osteoclast-mediated resorption. Here, we challenge this paradigm by demonstrating that a solitary clonal driver mutation simultaneously induces pathological bone formation and resorption, with osteosclerosis acting...

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Identifiers and source

Literature Corpus work
52178d98-e9d4-5b14-8dbc-4d2ea703f02f
DOI
10.64898/2026.03.19.712939
Open publication

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Oncodevelopmental plasticity of the skeleton in myeloid neoplasmsDOI 10.64898/2026.03.19.712939
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