Activin-dependent signaling in fibro/adipogenic progenitors causes fibrodysplasia ossificans progressiva

Abstract excerpt

Abstract Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal-dominant disorder characterized by progressive and profoundly disabling heterotopic ossification (HO). Here we show that fibro/adipogenic progenitors (FAPs) are a major cell-of-origin of HO in an accurate genetic mouse model of FOP ( Acvr1 tnR206H ). Targeted expression of the disease-causing type I bone morphogenetic protein (BMP) receptor,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Heterotopic Ossification and Related Conditions
• Share to Medical Imaging and Pathology Studies
• Share to Parathyroid Disorders and Treatments