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RANKL inhibition reduces lesional cellularity, Gαs variant expression and enables osteogenic maturation in fibrous dysplasia

2023-05-30

Abstract excerpt

<title>Abstract</title> <p>Fibrous dysplasia (FD) is a rare, disabling skeletal disease with no established treatments. Growing evidence supports inhibiting the osteoclastogenic factor receptor activator of nuclear Kappa-B ligand (RANKL) as a potential treatment strategy. In this study, we investigated mechanisms underlying RANKL neutralization with the monoclonal antibody denosumab on FD osteoprogenitors, by eva...

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Literature Corpus work
91cb62a7-c5fb-5e98-a3f8-7e67557d2ea1
DOI
10.21203/rs.3.rs-2977792/v1
Open publication

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RANKL inhibition reduces lesional cellularity, Gαs variant expression and enables osteogenic maturation in fibrous dysplasiaDOI 10.21203/rs.3.rs-2977792/v1
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