Article
Wnt/β-catenin signaling is differentially regulated by Gα proteins and contributes to fibrous dysplasia.
Proceedings of the National Academy of Sciences of the United States of America - 13 Dec 2011
Regard Jean B, Cherman Natasha, Palmer Daniel, Kuznetsov Sergei A, Celi Francesco S, Guettier Jean-Marc, Chen Min, Bhattacharyya Nisan, Wess Jurgen, Coughlin Shaun R, Weinstein Lee S, Collins Michael T, Robey Pamela G, Yang Yingzi
Abstract excerpt
Skeletal dysplasias are common disabling disorders characterized by aberrant growth of bone and cartilage leading to abnormal skeletal structures and functions, often attributable to defects in skeletal progenitor cells. The underlying molecular and cellular mechanisms of most skeletal dysplasias remain elusive. Although the Wnt/β-catenin signaling pathway is required for skeletal progenitor cells to...
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