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Article

Neoplastic fibrocytes play an essential role in bone marrow fibrosis in Jak2V617F-induced primary myelofibrosis mice.

Leukemia - 1 Feb 2021

Ozono Yoshinori, Shide Kotaro, Kameda Takuro, Kamiunten Ayako, Tahira Yuki, Sekine Masaaki, Akizuki Keiichi, Nakamura Kenichi, Iwakiri Hisayoshi, Sueta Mitsue, Hidaka Tomonori, Kubuki Yoko, Yamamoto Shojiro, Hasuike Satoru, Sawaguchi Akira, Nagata Kenji, Shimoda Kazuya

Abstract excerpt

Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) characterized by clonal myeloproliferation, progressive bone marrow (BM) fibrosis, splenomegaly, and anemia. BM fibrosis was previously thought to be a reactive phenomenon induced by mesenchymal stromal cells that are stimulated by the overproduction of cytokines such as transforming growth factor (TGF)-β1. However, the involvement of neoplastic...

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Identifiers

PMID: 32472085
DOI: 10.1038/s41375-020-0880-3
PMCID: PMC7862060

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