Article
Beryllium-Induced Hypersensitivity: Genetic Susceptibility and Neoantigen Generation.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2016
Fontenot Andrew P, Falta Michael T, Kappler John W, Dai Shaodong, McKee Amy S
Abstract excerpt
Chronic beryllium (Be) disease is a granulomatous lung disorder that results from Be exposure in a genetically susceptible host. The disease is characterized by the accumulation of Be-responsive CD4(+) T cells in the lung, and genetic susceptibility is primarily linked to HLA-DPB1 alleles possessing a glutamic acid at position 69 of the β-chain. Recent structural analysis of a Be-specific TCR interacting with a...
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