Chronic beryllium disease: immune-mediated destruction with implications for organ-specific autoimmunity.

doi:10.1046/j.1399-0039.2003.00160.x

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Article

Chronic beryllium disease: immune-mediated destruction with implications for organ-specific autoimmunity.

Tissue antigens - 1 Dec 2003

Fontenot A P, Kotzin B L

Abstract excerpt

Chronic beryllium disease (CBD) is caused by exposure to beryllium in the workplace and is characterized by an accumulation of beryllium-specific CD4+ T cells with granulomatous inflammation in the lung. Owing to its unique physical properties, beryllium is used in a variety of high-technology industries, and CBD continues to be an important public health concern. CBD develops in up to 16% of exposed workers,...

Topics

Autoimmune Diseases
Berylliosis
CD28 Antigens
CD4-Positive T-Lymphocytes
Chronic Disease
Genetic Predisposition to Disease
HLA-DP Antigens
Humans
Lung
Models, Molecular
Organ Specificity

Source

Open in PubMed

Identifiers

PMID: 14617028
DOI: 10.1046/j.1399-0039.2003.00160.x

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