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Article

Crystal structure of HLA-DP2 and implications for chronic beryllium disease.

Proceedings of the National Academy of Sciences of the United States of America - 20 Apr 2010

Dai Shaodong, Murphy Guinevere A, Crawford Frances, Mack Douglas G, Falta Michael T, Marrack Philippa, Kappler John W, Fontenot Andrew P

Abstract excerpt

Chronic beryllium disease (CBD) is a fibrotic lung disorder caused by beryllium (Be) exposure and is characterized by granulomatous inflammation and the accumulation of Be-responsive CD4(+) T cells in the lung. Genetic susceptibility to CBD has been associated with certain alleles of the MHCII molecule HLA-DP, especially HLA-DPB1*0201 and other alleles that contain a glutamic acid residue at position 69 of the...

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Identifiers

PMID: 20356827
DOI: 10.1073/pnas.1001772107
PMCID: PMC2867715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Crystal structure of HLA-DP2 and implications for chronic beryllium disease.PMID 20356827Read ↗

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Electrostatic potential on human leukocyte antigen: implications for putative mechanism of chronic beryllium disease.Semantic proximity Read ↗

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