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Article

Normal hematopoiesis and lack of β-catenin activation in osteoblasts of patients and mice harboring Lrp5 gain-of-function mutations.

Biochimica et biophysica acta - 1 Mar 2016

Galán-Díez Marta, Isa Adiba, Ponzetti Marco, Nielsen Morten Frost, Kassem Moustapha, Kousteni Stavroula

Abstract excerpt

Osteoblasts are emerging regulators of myeloid malignancies since genetic alterations in them, such as constitutive activation of β-catenin, instigate their appearance. The LDL receptor-related protein 5 (LRP5), initially proposed to be a co-receptor for Wnt proteins, in fact favors bone formation by suppressing gut-serotonin synthesis. This function of Lrp5 occurring in the gut is independent of β-catenin...

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Identifiers

PMID: 26681532
DOI: 10.1016/j.bbamcr.2015.11.037
PMCID: PMC4924618

Genes

HBM
LRP5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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