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Article

Lrp5 is not required for the proliferative response of osteoblasts to strain but regulates proliferation and apoptosis in a cell autonomous manner.

PloS one - 1 Jan 2012

Javaheri Behzad, Sunters Andrew, Zaman Gul, Suswillo Rosemary F L, Saxon Leanne K, Lanyon Lance E, Price Joanna S

Abstract excerpt

Although Lrp5 is known to be an important contributor to the mechanisms regulating bone mass, its precise role remains unclear. The aim of this study was to establish whether mutations in Lrp5 are associated with differences in the growth and/or apoptosis of osteoblast-like cells and their proliferative response to mechanical strain in vitro. Primary osteoblast-like cells were derived from cortical bone of adult...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Low Density Lipoprotein Receptor-Related Protein-5

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Source

Open in PubMed Open full text

Identifiers

PMID: 22567110
DOI: 10.1371/journal.pone.0035726
PMCID: PMC3342322

Genes

HBM
LRP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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