Article
Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts.
Nature - 13 Feb 2014
Kode Aruna, Manavalan John S, Mosialou Ioanna, Bhagat Govind, Rathinam Chozha V, Luo Na, Khiabanian Hossein, Lee Albert, Murty Vundavalli V, Friedman Richard, Brum Andrea, Park David, Galili Naomi, Mukherjee Siddhartha, Teruya-Feldstein Julie, Raza Azra, Rabadan Raul, Berman Ellin, Kousteni Stavroula
Abstract excerpt
Cells of the osteoblast lineage affect the homing and the number of long-term repopulating haematopoietic stem cells, haematopoietic stem cell mobilization and lineage determination and B cell lymphopoiesis. Osteoblasts were recently implicated in pre-leukaemic conditions in mice. However, a sing...
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