Article
Four Genome-Wide Association Studies Identify New Extreme Longevity Variants.
The journals of gerontology. Series A, Biological sciences and medical sciences - 12 Oct 2017
Sebastiani Paola, Gurinovich Anastasia, Bae Harold, Andersen Stacy, Malovini Alberto, Atzmon Gil, Villa Francesco, Kraja Aldi T, Ben-Avraham Danny, Barzilai Nir, Puca Annibale, Perls Thomas T
Abstract excerpt
The search for the genetic determinants of extreme human longevity has been challenged by the phenotype's rarity and its nonspecific definition by investigators. To address these issues, we established a consortium of four studies of extreme longevity that contributed 2,070 individuals who survived to the oldest one percentile of survival for the 1900 U.S. birth year cohort. We conducted various analyses to...
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