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Article

Minimal impact of age and housing temperature on the metabolic phenotype of Acc2-/- mice.

The Journal of endocrinology - 1 Mar 2016

Brandon Amanda E, Stuart Ella, Leslie Simon J, Hoehn Kyle L, James David E, Kraegen Edward W, Turner Nigel, Cooney Gregory J

Abstract excerpt

An important regulator of fatty acid oxidation (FAO) is the allosteric inhibition of CPT-1 by malonyl-CoA produced by the enzyme acetyl-CoA carboxylase 2 (ACC2). Initial studies suggested that deletion of Acc2 (Acacb) increased fat oxidation and reduced adipose tissue mass but in an independently generated strain of Acc2 knockout mice we observed increased whole-body and skeletal muscle FAO and a compensatory...

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Source

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Identifiers

PMID: 26668208
DOI: 10.1530/JOE-15-0444
PMCID: PMC4906541

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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