Article

Hepatocyte Angiotensinogen Deletion Protects Against Diet-induced Metabolic Disorders in Mice Under Thermoneutral Conditions

2026-08-09

Abstract excerpt

<h4>ABSTRACT</h4> Angiotensinogen (AGT) deletion in hepatocytes reduces Western diet–induced adiposity and hepatic steatosis in mice maintained under conventional room-temperature (RT) housing. Given the high metabolic activity of mice, this temperature imposes adaptive metabolic responses in this species. Whether this metabolic protection persists independent of increased thermogenic demand remains unclear. In t...

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Literature Corpus work: e919438f-1903-5651-8c86-6c47d11695a6
DOI: 10.64898/2026.08.04.742617

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