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Article

Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice.

Molecular and cellular biology - 1 Mar 2007

Harada Naomoto, Oda Zenjun, Hara Yoshikazu, Fujinami Koji, Okawa Mayumi, Ohbuchi Katsuya, Yonemoto Mari, Ikeda Yuika, Ohwaki Kenji, Aragane Katsumi, Tamai Yoshitaka, Kusunoki Jun

Abstract excerpt

Acetyl coenzyme A (acetyl-CoA) carboxylase (ACC) catalyzes carboxylation of acetyl-CoA to form malonyl-CoA. In mammals, two isozymes exist with distinct physiological roles: cytosolic ACC1 participates in de novo lipogenesis (DNL), and mitochondrial ACC2 is involved in negative regulation of mito...

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Identifiers

PMID: 17210641
DOI: 10.1128/MCB.01122-06
PMCID: PMC1820479

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17210641-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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